I "Dune Messiah" fortsætter Frank Herbert historien om Paul Atreides, der nu er kendt som den frygtede Muad'Dib. Som kejser af det kendte univers besidder han mere magt, end nogen anden mand nogensinde var bestemt til at have. Tilbedt som et religiøst ikon af de fanatiske Fremen, står Paul over for fjendskabet fra de politiske huse han fejede af banen, da han tog tronen og en faretruende konspiration blandt hans nærmeste. Da Atreides-huset begynder...

Centuries have passed but for humanity to continue to prosper, Leto, the son of Dune's savior, must make a tremendous sacrifice.

The desert planet Arrakis, called Dune, has been destroyed. The remnants of the Old Empire have been consumed by the violent matriarchal cult known as the Honored Matres. Only one faction remains a viable threat to their total conquest - the Bene Gesserit, heirs to Dune's power. Under the leadership of Mother Superior Darwi Odrade, the Bene Gesserit have colonised a green world on the planet Chapterhouse, and are turning it into a desert, mile by...