Stuart Little is a mouse in the family of the Frederick C. Littles and is a pleasant character, with a shy manner. His adventure starts when he tries to find his friend, Margalo, a little pretty bird.

The Little family adopts a spunky boy named Stuart who looks a lot like a mouse. Mr. and Mrs. Little adore their new son, but their older son George isn't so sure what to make of his new brother and devises a plan to get Stuart out of the house.