A once-successful musician living in New York faces the fact that her life might never get better and considers ending it all. In a last-ditch effort to find happiness and in her own uniquely sarcastic way, she faces her dead-end job, dating apps, her childhood, and her depression head-on to come back from the edge with a vengeance.

Details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor mistakenly artificially inseminates her during a checkup.